07:00 Registry Session Chairpersons: Terri Berk

Plenary session 1: Basic Science

Chairpersons: Mike Woods, Rolf Sijmons

08:00

Functional PMS2-PMS2CL-"hybrid"-alleles containing pseudogene-specific sequence variants account for a third of all alleles (download)

Katharina Wimmer

08:10

T cell immune response against frameshift-induced neopeptides in HNPCC (download)

Matthias Kloor

08:20

Humoral immune response against tumor-specific frameshift peptides in Hereditary Nonpolyposis Colorectal Cancer (download)

Miriam Reuschenbach

08:30

Molecular mechanisms underlying the differential expression of HLA class II antigens in microsatellite unstable colorectal carcinoma (download)

Sara Michel

08:40

Autosomal dominant form of MLH1 epimutation segregates with a genetic haplotype in a three-generation HNPCC family (download)

Megan Hitchins

08:50

Deletion of the 3’ exons of TACSTD1 causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 gene promoter methylation (download)

Suet Yi Leung

09:00

A novel cause of Lynch Syndrome: heritable somatic methylation of MSH2 due to deletion of the 3’ exons of the upstream gene (download)

Marjolijn Ligtenberg

09:10

A frequent germline EPCAM deletion causes Lynch Syndrome by hypermethylation of the MSH2 promotor (download)

Renée C. Niessen

09:20

General discussion

09:30 – 10:00 hrs Coffee break

10:00

Breaking news lecture

CAPP2 and Beyond

The Colon Cancer Stem Cell and Aspirin

Introduction by John Baron

John Burn

Riccardo Fodde

Plenary session 2: Clinical identification, cancer risk, modifiers

Chairpersons: Malcolm Dunlop, Maurizio Genuardi

10:30

Identification of novel genes involved in colorectal cancer predisposition (download)

Ramprasath Venkatachalam

10:40

Development and validation of a prediction model to estimate gene-specific risk in Lynch Syndrome (download)

Fay Kastrinos

10:50

Lynch syndrome cancer risks for MSH6 mutation carriers (download)

Mark A. Jenkins

11:00

Estimation of extra-colonic cancer risks in MLH1, MSH2 and MSH6 mutation carriers (download)

Christoph Engel

11:10

Haemochromatosis HFE gene polymorphisms as potential modifiers of Hereditary Nonpolyposis Colorectal Cancer risk and onset age (download)

Rodney J. Scott

11:20

Modifiers of colorectal cancer risk in Lynch Syndrome (download)

Juul Wijnen

11:30

Overweight and the development of colorectal tumours in Lynch Syndrome mutation carriers (download)

Akke Botma

11:40

Germline mutations in MMR-genes show association with prostate cancer (download)

Pål Møller

11:50

General discussion

12:00 – 13:00 hrs Lunch break & Posters

12:00 – 13:00 hrs Council meeting

13:00

Warthin lecture

Human Variome Project and recent developments

The InSiGHT LOVD database - live presentation

InSiGHT and recent developments

Introduction by Tom Weber

Richard Cotton

Johan den Dunnen

Finlay Macrae

Plenary session 3: Lynch Syndrome, Hyperplastic Polyposis

Chairpersons: Jukka Pekka Mecklin, Hans Vasen

14:00

Ten years after mutation testing for Lynch Syndrome: cancer incidence and outcome (download)

Heikki J. Järvinen

14:10

The outcome of longterm surveillance of Lynch Syndrome families in the Netherlands (download)

Hans Vasen

14:20

Natural history of Amsterdam patients folowing colorectal cancer resection (download)

Matthew F. Kalady

14:30

Serological markers in evaluation of individual risk of gastric cancer among mutation carriers in Lynch Syndrome (download)

Jukka-Pekka Mecklin

14:40

Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch Syndrome kindreds (download)

Eli Marie Grindedal

14:50

Family history of colorectal cancer is inversely related to polyp count in individuals with multiple serrated polyps (download)

Joanne Young

15:00

Increased colorectal cancer risk during follow-up in patients with hyperplastic polyposis syndrome: a multicentre cohort study (download)

K.S. Boparai

15:10

Narrow-band imaging improves the detection of polyps in patients with hyperplastic polyposis syndrome: a prospective randomized study (download)

K.S. Boparai

15:20

General discussion

15:30 – 16:00 hrs Coffee Break

16:00

IH – Ten years after

Chairpersons Steve Thibodeau, Ian Frayling

16:00

Mismatch repair gene protein expression in young patients with colorectal cancer: the eight year Auckland experience (download)

Susan Parry

16:10

Interobserver variability in the interpretation of immunohistochemical Mismatch Repair Protein staining (download)

Louise Klarskov

16: 20

Initial experiences of the UK national external quality assessment scheme for immunocytochemistry of DNA mismatch repair proteins (download)

Ian M Frayling

16:30

Meera Khan Lecture

"Development and Status of the German HNPCC Consortium"

Introduction by Gabriela Möslein

Peter Propping